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Article

A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding.

The Journal of biological chemistry - 26 Nov 2010

Zhu Li, Millen Linda, Mendoza Juan L, Thomas Philip J

Abstract excerpt

Early onset dystonia is commonly associated with the deletion of one of a pair of glutamate residues (ΔE302/303) near the C terminus of torsinA, a member of the AAA+ protein family (ATPases associated with a variety of cellular activities) located in the endoplasmic reticulum lumen. The functional consequences of the disease-causing mutation, ΔE, are not currently understood. By contrast to other AAA+ proteins,...

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Identifiers

PMID: 20861018
DOI: 10.1074/jbc.M110.123471
PMCID: PMC2988333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding.PMID 20861018Read ↗

The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein.Semantic proximity Read ↗

Effects of genetic variations in the dystonia protein torsinA: identification of polymorphism at residue 216 as protein modifier.Semantic proximity Read ↗

Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis.Semantic proximity Read ↗

Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.Semantic proximity Read ↗

Dystonia-associated forms of torsinA are deficient in ATPase activity.Semantic proximity Read ↗

Biochemical and cellular analysis of human variants of the DYT1 dystonia protein, TorsinA/TOR1A.Semantic proximity Read ↗

Regulation of Torsin ATPases by LAP1 and LULL1Semantic proximity Read ↗

The role of torsinA in dystonia.Semantic proximity Read ↗

Consequences of the DYT1 mutation on torsinA oligomerization and degradation.Semantic proximity Read ↗

The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Semantic proximity Read ↗

TorsinA and dystonia: from nuclear envelope to synapseSemantic proximity Read ↗

TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast.Semantic proximity Read ↗

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