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Article

Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen.

Circulation - 4 Jan 2011

Peal David S, Mills Robert W, Lynch Stacey N, Mosley Janet M, Lim Evi, Ellinor Patrick T, January Craig T, Peterson Randall T, Milan David J

Abstract excerpt

BACKGROUND: Genetic long QT (LQT) syndrome is a life-threatening disorder caused by mutations that result in prolongation of cardiac repolarization. Recent work has demonstrated that a zebrafish model of LQT syndrome faithfully recapitulates several features of human disease, including prolongation of ventricular action potential duration, spontaneous early afterdepolarizations, and 2:1 atrioventricular block in...

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Chlorocebus aethiops
ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels
Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Screening Assays

Long QT Syndrome

Zebrafish Proteins

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Identifiers

PMID: 21098441
DOI: 10.1161/CIRCULATIONAHA.110.003731
PMCID: PMC3015011

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KCNH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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