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Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome

1 Jul 2015

Abstract excerpt

Mutations in a voltage-gated sodium channel (SCN1A) result in Dravet Syndrome (DS), a catastrophic childhood epilepsy. Zebrafish with a mutation in scn1Lab recapitulate salient phenotypes associated with DS, including seizures, early fatality, and resistance to antiepileptic drugs. To discover new drug candidates for the treatment of DS, we screened a chemical library of ∼1000 compounds and identified 4 compounds...

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Neonatal and fetal brain pathology
Neuroscience and Neuropharmacology Research
Zebrafish Biomedical Research Applications

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26465006
DOI: 10.1523/eneuro.0068-15.2015

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