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Article

A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder.

BMC systems biology - 19 Nov 2010

McEachin Richard C, Chen Haiming, Sartor Maureen A, Saccone Scott F, Keller Benjamin J, Prossin Alan R, Cavalcoli James D, McInnis Melvin G

Abstract excerpt

BACKGROUND: Lithium is an effective treatment for Bipolar Disorder (BD) and significantly reduces suicide risk, though the molecular basis of lithium's effectiveness is not well understood. We seek to improve our understanding of this effectiveness by posing hypotheses based on new experimental data as well as published data, testing these hypotheses in silico, and posing new hypotheses for validation in future...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21092101
DOI: 10.1186/1752-0509-4-158
PMCID: PMC3212423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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