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Article

Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?

Annals of the New York Academy of Sciences - 1 Dec 2010

Alcaïs Alexandre, Quintana-Murci Lluis, Thaler David S, Schurr Erwin, Abel Laurent, Casanova Jean-Laurent

Abstract excerpt

The hypothesis that inborn errors of immunity underlie infectious diseases is gaining experimental support. However, the apparent modes of inheritance of predisposition or resistance differ considerably among diseases and among studies. A coherent genetic architecture of infectious diseases is lacking. We suggest here that life-threatening infectious diseases in childhood, occurring in the course of primary...

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Identifiers

PMID: 21091717
DOI: 10.1111/j.1749-6632.2010.05834.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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