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Article

Severe infectious diseases of childhood as monogenic inborn errors of immunity.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2015

Casanova Jean-Laurent

Abstract excerpt

This paper reviews the developments that have occurred in the field of human genetics of infectious diseases from the second half of the 20th century onward. In particular, it stresses and explains the importance of the recently described monogenic inborn errors of immunity underlying resistance or susceptibility to specific infections. The monogenic component of the genetic theory provides a plausible...

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Identifiers

PMID: 26621750
DOI: 10.1073/pnas.1521651112
PMCID: PMC4697435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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