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Article

Human genetics of infectious diseases: a unified theory.

The EMBO journal - 21 Feb 2007

Casanova Jean-Laurent, Abel Laurent

Abstract excerpt

Since the early 1950s, the dominant paradigm in the human genetics of infectious diseases postulates that rare monogenic immunodeficiencies confer vulnerability to multiple infectious diseases (one gene, multiple infections), whereas common infections are associated with the polygenic inheritance of multiple susceptibility genes (one infection, multiple genes). Recent studies, since 1996 in particular, have...

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Identifiers

PMID: 17255931
DOI: 10.1038/sj.emboj.7601558
PMCID: PMC1852849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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