Human genetics of infectious diseases: between proof of principle and paradigm.

doi:10.1172/JCI38111

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Article

Human genetics of infectious diseases: between proof of principle and paradigm.

The Journal of clinical investigation - 1 Sept 2009

Alcaïs Alexandre, Abel Laurent, Casanova Jean-Laurent

Abstract excerpt

The observation that only a fraction of individuals infected by infectious agents develop clinical disease raises fundamental questions about the actual pathogenesis of infectious diseases. Epidemiological and experimental evidence is accumulating to suggest that human genetics plays a major role in this process. As we discuss here, human predisposition to infectious diseases seems to cover a continuous spectrum...

Topics

Communicable Diseases
Female
Genetic Predisposition to Disease
Genetics, Medical
Genome, Human
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Immunologic Deficiency Syndromes
Male
Models, Genetic
Pedigree

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Identifiers

PMID: 19729848
DOI: 10.1172/JCI38111
PMCID: PMC2735901

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