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Article

Human genetics of infectious diseases: between proof of principle and paradigm.

The Journal of clinical investigation - 1 Sept 2009

Alcaïs Alexandre, Abel Laurent, Casanova Jean-Laurent

Abstract excerpt

The observation that only a fraction of individuals infected by infectious agents develop clinical disease raises fundamental questions about the actual pathogenesis of infectious diseases. Epidemiological and experimental evidence is accumulating to suggest that human genetics plays a major role in this process. As we discuss here, human predisposition to infectious diseases seems to cover a continuous spectrum...

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Identifiers

PMID: 19729848
DOI: 10.1172/JCI38111
PMCID: PMC2735901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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