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Article

A neuroprotective role for angiogenin in models of Parkinson’s disease

19 Nov 2010

Abstract excerpt

We previously observed marked down-regulation of the mRNA for angiogenin, a potent inducer of neovascularization, in a mouse model of Parkinson's disease (PD) based on over-expression of alpha-synuclein. Angiogenin has also been recently implicated in the pathogenesis of amyotrophic lateral sclerosis. In this study, we confirmed that mouse angiogenin-1 protein is dramatically reduced in this transgenic...

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PMID: 21091473
DOI: 10.1111/j.1471-4159.2010.07112.x

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