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Article

Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing.

Protein & cell - 1 Feb 2010

Ono Koh, Wang Xiaofei, Kim Sung Ouk, Armstrong Lucas C, Bornstein Paul, Han Jiahuai

Abstract excerpt

Metaxin, a mitochondrial outer membrane protein, is critical for TNF-induced cell death in L929 cells. Its deficiency, caused by retroviral insertion-mediated mutagenesis, renders L929 cells resistance to TNF killing. In this study, we further characterized metaxin deficiency-caused TNF resistance in parallel with Bcl-X(L) overexpression-mediated death resistance. We did not find obvious change in mitochondria...

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Source

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Identifiers

PMID: 21088703
DOI: 10.1007/s13238-010-0017-y
PMCID: PMC2982194

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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