Article

Acquired and intrinsic resistance to vemurafenib in BRAF <sup>V600E</sup> -driven melanoma brain metastases

2022-12-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> BRAF V600 -mutated melanoma brain metastases (MBMs) are responsive to BRAF inhibitors, but responses are generally less durable than those of extracranial metastases. We here tested the hypothesis that the drug efflux transporters P-glycoprotein (P-gp; ABCB1) and breast cancer resistance protein (BCRP;ABCG2) expressed at the blood–brain barrier (BBB) offer MBMs protection from...

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Literature Corpus work: aea58e44-4551-5bcc-af80-d7950c0b2f68
DOI: 10.1101/2022.12.20.521202

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