Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial.

doi:10.1016/S1470-2045(12)70431-X

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Article

Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial.

The Lancet. Oncology - 1 Nov 2012

Long Georgina V, Trefzer Uwe, Davies Michael A, Kefford Richard F, Ascierto Paolo A, Chapman Paul B, Puzanov Igor, Hauschild Axel, Robert Caroline, Algazi Alain, Mortier Laurent, Tawbi Hussein, Wilhelm Tabea, Zimmer Lisa, Switzky Julie, Swann Suzanne, Martin Anne-Marie, Guckert Mary, Goodman Vicki, Streit Michael, Kirkwood John M, Schadendorf Dirk

Abstract excerpt

BACKGROUND: Brain metastases are common in patients with metastatic melanoma and median overall survival from their diagnosis is typically 17-22 weeks. We assessed dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain. METHODS: We undertook a multicentre, open-label, phase 2 trial in 24 centres in six countries. We enrolled patients with histologically confirmed Val600Glu...

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PMID: 23051966
DOI: 10.1016/S1470-2045(12)70431-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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