Article
Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment.
The Journal of antimicrobial chemotherapy - 1 Jan 2011
Soon Rachel L, Nation Roger L, Cockram Stewart, Moffatt Jennifer H, Harper Marina, Adler Ben, Boyce John D, Larson Ian, Li Jian
Abstract excerpt
OBJECTIVES: electrostatic forces mediate the initial interaction between cationic colistin and Gram-negative bacterial cells. Lipopolysaccharide (LPS) loss mediates colistin resistance in some A. baumannii strains. Our aim was to determine the surface charge of colistin-susceptible and -resistant A. baumannii as a function of growth phase and in response to polymyxin treatment. METHODS: the zeta potential of A....
Topics
- Acinetobacter Infections
- Acinetobacter baumannii
- Anti-Bacterial Agents
- Colistin
- Drug Resistance, Multiple, Bacterial
- Electricity
- Genes, Bacterial
- Humans
- Lipopolysaccharides
- Microbial Sensitivity Tests
- Mutation
- Static Electricity