Article
Cell surface hydrophobicity of colistin-susceptible vs resistant Acinetobacter baumannii determined by contact angles: methodological considerations and implications.
Journal of applied microbiology - 1 Oct 2012
Soon R L, Li J, Boyce J D, Harper M, Adler B, Larson I, Nation R L
Abstract excerpt
Contact angle analysis of cell surface hydrophobicity (CSH) describes the tendency of a water droplet to spread across a lawn of filtered bacterial cells. Colistin-induced disruption of the Gram-negative outer membrane necessitates hydrophobic contacts with lipopolysaccharide (LPS). We aimed to characterize the CSH of Acinetobacter baumannii using contact angles, to provide insight into the mechanism of colistin...
Topics
- Acinetobacter baumannii
- Anti-Bacterial Agents
- Cell Membrane
- Colistin
- Drug Resistance, Bacterial
- Hydrophobic and Hydrophilic Interactions
- Lipopolysaccharides
- Microscopy, Atomic Force
- Phenotype