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Article

Transition of colistin dependence into colistin resistance in Acinetobacter baumannii.

Scientific reports - 27 Oct 2017

Lee Ji-Young, Chung Eun Seon, Ko Kwan Soo

Abstract excerpt

We recently demonstrated a high rate of colistin dependence in Acinetobacter baumannii isolates exposed to colistin in vitro. In the present study, we obtained a colistin-resistant (H08-391R) and colistin-dependent mutant (H08-391D) from a colistin-susceptible parental strain (H08-391). We found that the colistin-dependent mutant converted into a stable colistin-resistant mutant (H08-391D-R) in vitro after four...

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Identifiers

PMID: 29079752
DOI: 10.1038/s41598-017-14609-0
PMCID: PMC5660220

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