Article
Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus.
PloS one - 1 Jan 2016
Kerviel Adeline, Dash Shantoshini, Moncorgé Olivier, Panthu Baptiste, Prchal Jan, Décimo Didier, Ohlmann Théophile, Lina Bruno, Favard Cyril, Decroly Etienne, Ottmann Michèle, Roingeard Philippe, Muriaux Delphine
Abstract excerpt
The influenza A(H1N1)pdm09 virus caused the first influenza pandemic of the 21st century. In this study, we wanted to decipher the role of conserved basic residues of the viral M1 matrix protein in virus assembly and release. M1 plays many roles in the influenza virus replication cycle. Specifically, it participates in viral particle assembly, can associate with the viral ribonucleoprotein complexes and can bind...
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