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Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations

16 Nov 2010

Abstract excerpt

Two strategies to control mosquito-borne diseases, such as malaria and dengue fever, are reducing mosquito population sizes or replacing populations with disease-refractory varieties. We propose a genetic system, Semele, which may be used for both. Semele consists of two components: a toxin expressed in transgenic males that either kills or renders infertile wild-type female recipients and an antidote expressed...

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Share to Insect and Arachnid Ecology and Behavior
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PMID: 21078687
DOI: 10.1534/genetics.110.124479

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