The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.

doi:10.1073/pnas.87.6.2112

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Article

The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990

Mazo A M, Huang D H, Mozer B A, Dawid I B

Abstract excerpt

The trithorax (trx) gene functions in segment determination in Drosophila through interaction with genes of the bithorax complex and Antennapedia complex. Genetic evidence suggests that trx may be considered a positive regulator of homeotic genes. Sequencing of cDNAs corresponding to the entire trx transcription unit revealed the existence of an unusually long open reading frame encoding 3759 amino acids. The...

Topics

Amino Acid Sequence
Animals
Cloning, Molecular
DNA
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Gene Expression
Genes
Metalloproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nervous System

Recombinant Fusion Proteins

Sequence Homology, Nucleic Acid

Transcription Factors

Zinc

Source

Open in PubMed Open full text

Identifiers

PMID: 2107543
DOI: 10.1073/pnas.87.6.2112
PMCID: PMC53636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2107543-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.PMID 2107543Read ↗

The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins.Semantic proximity Read ↗

Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each.Semantic proximity Read ↗

The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax.Semantic proximity Read ↗

The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites.Semantic proximity Read ↗

A homeotic mutation in the trithorax SET domain impedes histone binding.Semantic proximity Read ↗

Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes.Semantic proximity Read ↗

The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein.Semantic proximity Read ↗

Function of the C. elegans T-box factor TBX-2 depends on interaction with the UNC-37/Groucho corepressor.Semantic proximity Read ↗

The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity.Semantic proximity Read ↗

TnaA, an SP-RING protein, interacts with Osa, a subunit of the chromatin remodeling complex BRAHMA and with the SUMOylation pathway in Drosophila melanogaster.Semantic proximity Read ↗

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Functional evolution of the Ultrabithorax protein.Semantic proximity Read ↗

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