Article
The signal for glucose repression of the lactose-galactose regulon is amplified through subtle modulation of transcription of the Kluyveromyces lactis Kl-GAL4 activator gene.
Molecular and cellular biology - 1 May 1992
Kuzhandaivelu N, Jones W K, Martin A K, Dickson R C
Abstract excerpt
Induction of the lactose-galactose regulon is strongly repressed by glucose in some but not all strains of Kluyveromyces lactis. We show here that in strongly repressed strains, two to three times less Kl-GAL4 mRNA is synthesized and that expression of structural genes in the regulon such as LAC4...
Topics
- Alleles
- Base Sequence
- Fungal Proteins
- Genes, Fungal
- Genes, Regulator
- Glucose
- Kluyveromyces
- Lactose
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Promoter Regions, Genetic
- RNA, Fungal
- Regulatory Sequences, Nucleic Acid
- TATA Box