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Article

Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models.

Virology - 5 Feb 2011

Ma Wenjun, Lager Kelly M, Li Xi, Janke Bruce H, Mosier Derek A, Painter Laura E, Ulery Eva S, Ma Jingqun, Lekcharoensuk Porntippa, Webby Richard J, Richt Jürgen A

Abstract excerpt

PB2 627K is a determinant of influenza host range and contributes to the pathogenicity of human-, avian-, and mouse-adapted influenza viruses in the mouse model. Here we used mouse and pig models to analyze the contribution of a swine-origin and avian-origin PB2 carrying either 627K or 627E in th...

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Identifiers

PMID: 21074235
DOI: 10.1016/j.virol.2010.10.027
PMCID: PMC3033585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21074235-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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