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Article

A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells.

The Journal of general virology - 1 Feb 2011

Nagashima Shigeo, Takahashi Masaharu, Jirintai, Tanaka Toshinori, Yamada Kentaro, Nishizawa Tsutomu, Okamoto Hiroaki

Abstract excerpt

We have previously demonstrated that the release of hepatitis E virus (HEV) from infected cells depended on ORF3 protein, which harbours one or two PSAP motifs. To elucidate the PSAP motif(s) in the ORF3 protein during virion egress, five PSAP mutants derived from an infectious genotype 3 cDNA clone of pJE03-1760F/wt that can grow efficiently in PLC/PRF/5 cells were analysed. Four mutants, including mutLSAP,...

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Share to Gene Expression Regulation, Viral
Share to Hepatitis E virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutagenesis, Site-Directed

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Share to Sequence Alignment

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Source

Identifiers

PMID: 21068219
DOI: 10.1099/vir.0.025791-0

Genes

PSAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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