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Article

ORF3 protein of hepatitis E virus is essential for virion release from infected cells

10 Jul 2009

Abstract excerpt

The function of the hepatitis E virus (HEV) open reading frame 3 (ORF3) protein remains unclear. To elucidate the role of the ORF3 protein in the virus life cycle, an infectious cDNA clone (pJE03-1760F/wt) that can replicate efficiently in PLC/PRF/5 and A549 cells and release progeny into the culture medium was used to generate a derivative ORF3-deficient (DeltaORF3) mutant whose third in-frame AUG codon of ORF3...

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PMID: 19339479
DOI: 10.1099/vir.0.010561-0

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