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Article

Modulation of cellular autophagy by genotype 1 hepatitis E virus ORF3 protein.

The Journal of general virology - 1 Feb 2023

Srivastava Manjita, Bhukya Prudhvi Lal, Barman Muneesh Kumar, Bhise Neha, Lole Kavita S

Abstract excerpt

Hepatitis E virus (HEV) egresses from infected hepatocytes as quasienveloped particles containing open reading frame 3 (ORF3) protein. HEV ORF3 (small phosphoprotein) interacts with host proteins to establish a favourable environment for virus replication. It is a functional viroporin that plays an important role during virus release. Our study provides evidence that pORF3 plays a pivotal role in inducing...

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Identifiers

PMID: 36809248
DOI: 10.1099/jgv.0.001824

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