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A missense mutation of the <i>Dhh</i> gene is associated with male pseudohermaphroditic rats showing impaired Leydig cell development

9 Nov 2010

Abstract excerpt

Development of the male gonads is a complex process with interaction of various cells in the gonads including germ, Sertoli, Leydig, and myoid cells. TF is a mutant rat strain showing male pseudohermaphroditism, with agenesis of Leydig cells and androgen deficiency controlled by an autosomal single recessive gene (mp). The mp locus was mapped on the distal region of rat chromosome 7 by linkage analysis, but the...

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PMID: 21062903
DOI: 10.1530/rep-10-0006

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