Article
Relationship between protein synthesis and concentrations of charged and uncharged tRNATrp in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990
Rojiani M V, Jakubowski H, Goldman E
Abstract excerpt
We have continuously monitored Trp-tRNA(Trp) concentrations in vivo and, in the same cultures, measured rates of protein synthesis in isogenic stringent and relaxed strains. We have also manipulated cellular charged and uncharged [tRNA(Trp)] by two means: (i) the strain used contains a Trp-tRNA synthetase mutation that increases the Km for Trp; thus, varying exogenous Trp varies cellular Trp-tRNA(Trp); and (ii)...
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