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Article

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2010

Pfaff Elke, Remke Marc, Sturm Dominik, Benner Axel, Witt Hendrik, Milde Till, von Bueren André O, Wittmann Andrea, Schöttler Anna, Jorch Norbert, Graf Norbert, Kulozik Andreas E, Witt Olaf, Scheurlen Wolfram, von Deimling Andreas, Rutkowski Stefan, Taylor Michael D, Tabori Uri, Lichter Peter, Korshunov Andrey, Pfister Stefan M

Abstract excerpt

PURPOSE: The role of TP53 mutations in the tumorigenesis of sporadic medulloblastoma (MB) and the value of TP53 mutation status as a prognostic marker are not yet definitely elucidated. A recent report identified TP53 mutations in MB as an adverse prognostic marker. Hence, the current study was c...

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Source

Identifiers

PMID: 21060032
DOI: 10.1200/JCO.2010.31.1670

Genes

CTNNB1
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21060032-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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