Article
Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 2010
Tomaszewski Maciej, Debiec Radoslaw, Braund Peter S, Nelson Christopher P, Hardwick Robert, Christofidou Paraskevi, Denniff Matthew, Codd Veryan, Rafelt Suzanne, van der Harst Pim, Waterworth Dawn, Song Kijoung, Vollenweider Peter, Waeber Gerard, Zukowska-Szczechowska Ewa, Burton Paul R, Mooser Vincent, Charchar Fadi J, Thompson John R, Tobin Martin D, Samani Nilesh J
Abstract excerpt
Genetic determinants of blood pressure are poorly defined. We undertook a large-scale, gene-centric analysis to identify loci and pathways associated with ambulatory systolic and diastolic blood pressure. We measured 24-hour ambulatory blood pressure in 2020 individuals from 520 white European nuclear families (the Genetic Regulation of Arterial Pressure of Humans in the Community Study) and genotyped their DNA...
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