Article
Two further blood pressure loci identified in ion channel genes with a gene-centric approach.
Circulation. Cardiovascular genetics - 1 Dec 2014
McCarthy Nina S, Vangjeli Ciara, Cavalleri Gianpiero L, Delanty Norman, Shianna Kevin V, Surendran Praveen, O'Brien Eoin, Munroe Patricia B, Masca Nicholas, Tomaszewski Maciej, Samani Nilesh J, Stanton Alice V
Abstract excerpt
BACKGROUND: Blood pressure (BP) is highly heritable, but our understanding of the genetic causes underlying variations in BP is incomplete. In this study, we explored whether novel loci associated with BP could be identified using a genecentric approach in 3 community-based cohorts with accurate BP measurements. METHODS AND RESULTS: Genotyping of 1857 single nucleotide polymorphisms (SNPs) in 91 ion channel genes...
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