Article
Interaction of wild-type and catalytically inactive mutant forms of tissue-type plasminogen activator with human umbilical vein endothelial cell monolayers.
The Journal of biological chemistry - 15 Feb 1990
Ramakrishnan V, Sinicropi D V, Dere R, Darbonne W C, Bechtol K B, Baker J B
Abstract excerpt
Several groups have demonstrated that radioiodinated tissue-type plasminogen activator (t-PA) binds to saturable sites on human umbilical vein endothelial cells (HUVECs) in culture (Hajjar, K. A., Hamel, N. M., Harpel, P. C., and Nachman, R. L. (1987) J. Clin. Invest. 80, 1712-1719; Beebe, D. P. (1987) Thromb. Res. 46, 241-254; Barnathan, E. S., Kuo, A., van der Keyl, H., McCrae, K. R., Larsen, G. L., and Cines,...
Topics
- Cells, Cultured
- Endothelium, Vascular
- Humans
- Kinetics
- Molecular Weight
- Mutation
- Plasminogen Inactivators
- Protein Binding
- Tissue Plasminogen Activator
- Umbilical Veins