Binding of mutant tissue-type plasminogen activators to human endothelial cells and their extracellular matrix.

doi:10.1016/s0024-3205(00)80007-7

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Article

Binding of mutant tissue-type plasminogen activators to human endothelial cells and their extracellular matrix.

Life sciences - 1 Jan 2000

Fukao H, Ueshima S, Okada K, Matsuo O

Abstract excerpt

We previously demonstrated that tissue-type plasminogen activator (t-PA) specifically bound to its receptor (t-PAR) on human umbilical vein endothelial cells (HUVEC). In addition to analyses of t-PA binding to plasminogen activator inhibitor-1 (PAI-1) in the extracellular matrix (ECM) and to the t-PAR, we further evaluated the binding of three t-PA mutants, deltaFE1X t-PA lacking finger (F), epidermal growth...

Topics

Aminocaproic Acid
Animals
Antifibrinolytic Agents
CHO Cells
Cells, Cultured
Cricetinae
Endothelium, Vascular
Extracellular Matrix
Humans
Iodine Radioisotopes
Mutation
Plasminogen Activator Inhibitor 1
Tissue Plasminogen Activator
Umbilical Veins

Source

Open in PubMed

Identifiers

PMID: 10894090
DOI: 10.1016/s0024-3205(00)80007-7

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