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Article

Dual nuclear import mechanisms of sex determining factor SRY: intracellular Ca2+ as a switch.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2011

Kaur Gurpreet, Jans David A

Abstract excerpt

The sex-determining region on the Y chromosome (SRY) has 2 nuclear localization signals (NLSs) that flank the DNA binding high mobility group (HMG) domain; the β-NLS and the CaM-NLS, which mediate nuclear transport through importin β1 (Impβ1) and the calcium-binding protein calmodulin (CaM), respectively. Here we reconstitute the nuclear import mediated by the 2 NLSs for the first time in vitro, establishing Ran...

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Source

Identifiers

PMID: 21051653
DOI: 10.1096/fj.10-173351

Genes

SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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