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Article

Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2005

Sim Helena, Rimmer Kieran, Kelly Sabine, Ludbrook Louisa M, Clayton Andrew H A, Harley Vincent R

Abstract excerpt

The sex-determining region of the Y chromosome (SRY) plays a key role in human sex determination, as mutations in SRY can cause XY sex reversal. Although some SRY missense mutations affect DNA binding and bending activities, it is unclear how others contribute to disease. The high mobility group domain of SRY has two nuclear localization signals (NLS). Sex-reversing mutations in the NLSs affect nuclear import in...

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Source

Identifiers

PMID: 15746192
DOI: 10.1210/me.2004-0334

Genes

SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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