Article
A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal.
The Journal of biological chemistry - 5 Sept 2003
Argentaro Anthony, Sim Helena, Kelly Sabine, Preiss Scott, Clayton Andrew, Jans David A, Harley Vincent R
Abstract excerpt
During mammalian sex determination, SOX9 is translocated into the nuclei of Sertoli cells within the developing XY gonad. The N-terminal nuclear localization signal (NLS) is contained within a SOX consensus calmodulin (CaM) binding region, thereby implicating CaM in nuclear import of SOX9. By fluorescence spectroscopy and glutaraldehyde cross-linking, we show that the SOX9 HMG domain and CaM interact in vitro....
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