Article
KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patients.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2011
Xu Rui Feng, Sun Ji Ping, Zhang Shi Rong, Zhu Guan Shan, Li Li Bo, Liao Yu Lin, Xie Jian Ming, Liao Wang Jun
Abstract excerpt
Cholangiocarcinoma (CCA) is a rare but lethal malignancy arising from the biliary tract epithelium. It has a poor prognosis largely due to the difficulties of early diagnosis and the lack of effective therapies. It is thus imperative to develop new and effective treatments for CCA, which depends heavily on the mechanistic understanding of the disease. Previous studies have suggested that somatic mutations in...
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