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Article

Lack of consistent association of thyrotropin receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism.

Journal of endocrinological investigation - 1 Apr 2010

Lueblinghoff J, Mueller S, Sontheimer J, Paschke R

Abstract excerpt

BACKGROUND: Up to date, 14 patients with sporadic non-autoimmune hyperthyroidism (SNAH) caused by sporadic germline mutations in the TSH receptor (TSHR) gene have been reported. Despite considerable differences in the activity of hyperthyroidism, all SNAH case reports concluded that the demonstrated constitutive activity explains the phenotype. AIM: Recently, linear regression analysis (LRA) of constitutive...

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Source

Identifiers

PMID: 19636218
DOI: 10.1007/BF03345784

Genes

TSHR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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