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Article

Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome.

Genome research - 1 Dec 2010

Mercer Tim R, Dinger Marcel E, Bracken Cameron P, Kolle Gabriel, Szubert Jan M, Korbie Darren J, Askarian-Amiri Marjan E, Gardiner Brooke B, Goodall Gregory J, Grimmond Sean M, Mattick John S

Abstract excerpt

The complexity of the eukaryotic transcriptome is generated by the interplay of transcription initiation, termination, alternative splicing, and other forms of post-transcriptional modification. It was recently shown that RNA transcripts may also undergo cleavage and secondary 5' capping. Here, we show that post-transcriptional cleavage of RNA contributes to the diversification of the transcriptome by generating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21045082
DOI: 10.1101/gr.112128.110
PMCID: PMC2989990

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