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Article

Acrosome reaction: relevance of zona pellucida glycoproteins

1 Nov 2010

Abstract excerpt

During mammalian fertilisation, the zona pellucida (ZP) matrix surrounding the oocyte is responsible for the binding of the spermatozoa to the oocyte and induction of the acrosome reaction (AR) in the ZP-bound spermatozoon. The AR is crucial for the penetration of the ZP matrix by spermatozoa. The ZP matrix in mice is composed of three glycoproteins designated ZP1, ZP2 and ZP3, whereas in humans, it is composed...

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PMID: 21042299
DOI: 10.1038/aja.2010.72

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