Article
Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancer.
Annals of the New York Academy of Sciences - 1 Mar 2003
Moore Lee E, Huang Wen-Yi, Chung Joyce, Hayes Richard B
Abstract excerpt
Epidemiologic studies in human populations have identified a broad spectrum of risk factors for cancer. Gene-damaging agents have been a primary focus of cancer epidemiology; however, all xenobiotics do not interact with DNA directly. Some exogenous agents induce epigenetic changes. In view of this, markers that measure changes to the epigenome must also be incorporated into molecular epidemiologic studies. We...
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