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Article

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement

12 Apr 2007

Abstract excerpt

Cellular DNA damage triggers the DNA damage response pathway and leads to enforcement of cell cycle checkpoints, which are essential for the maintenance of genomic integrity and are activated in early stages of tumorigenesis. A special feature of prostate cancer is its high incidence and multifocality. To address the functionality of DNA damage checkpoints in the prostate, we analyzed the responses of human...

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PMID: 17431037
DOI: 10.1073/pnas.0609299104

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Source receipt: pubmed, retrieved 7 Sept 2026.

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