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Article

Pervasive cryptic epistasis in molecular evolution.

PLoS genetics - 21 Oct 2010

Lunzer Mark, Golding G Brian, Dean Antony M

Abstract excerpt

The functional effects of most amino acid replacements accumulated during molecular evolution are unknown, because most are not observed naturally and the possible combinations are too numerous. We created 168 single mutations in wild-type Escherichia coli isopropymalate dehydrogenase (IMDH) that...

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Share to Amino Acid Substitution
Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutagenesis, Site-Directed

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Share to Sequence Homology, Amino Acid

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Identifiers

PMID: 20975933
DOI: 10.1371/journal.pgen.1001162
PMCID: PMC2958800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20975933-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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