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Article

Human immune responses that reduce the transmission of Plasmodium falciparum in African populations

26 Oct 2010

Abstract excerpt

Malaria-infected individuals can develop antibodies which reduce the infectiousness of Plasmodium gametocytes to biting Anopheles mosquitoes. When ingested in a bloodmeal together with gametocytes, these antibodies reduce or prevent subsequent parasite maturation in the insect host. This transmission-blocking immunity is usually measured in human sera by testing its effect on the infectivity of gametocytes grown...

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PMID: 20974145
DOI: 10.1016/j.ijpara.2010.09.008

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