Article
Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein 1.
Infection and immunity - 1 May 2004
Johnson Armead H, Leke Rose G F, Mendell Nancy R, Shon Dewon, Suh Young Ju, Bomba-Nkolo Dennis, Tchinda Viviane, Kouontchou Samuel, Thuita Lucy W, van der Wel Anne Marie, Thomas Alan, Stowers Anthony, Saul Allan, Zhou Ainong, Taylor Diane W, Quakyi Isabella A
Abstract excerpt
The apical membrane antigen 1 (AMA1), merozoite surface antigen 2 (MSA2), and merozoite surface protein 1 (MSP1) are asexual-stage proteins currently being evaluated for inclusion in a vaccine for Plasmodium falciparum. Accordingly, it is important to understand factors that control antibody responses to these antigens. Antibody levels in plasma from residents of Etoa, Cameroon, between the ages of 5 and 70...
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