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Article

Interruption of inositol sphingolipid synthesis triggers Stt4p-dependent protein kinase C signaling.

The Journal of biological chemistry - 31 Dec 2010

Jesch Stephen A, Gaspar Maria L, Stefan Christopher J, Aregullin Manuel A, Henry Susan A

Abstract excerpt

The protein kinase C (PKC)-MAPK signaling cascade is activated and is essential for viability when cells are starved for the phospholipid precursor inositol. In this study, we report that inhibiting inositol-containing sphingolipid metabolism, either by inositol starvation or treatment with agents that block sphingolipid synthesis, triggers PKC signaling independent of sphingoid base accumulation. Under these...

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Identifiers

PMID: 20972263
DOI: 10.1074/jbc.M110.188607
PMCID: PMC3009921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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