STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae.

doi:10.1074/jbc.272.44.27671

Back to search

Article

STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae.

The Journal of biological chemistry - 31 Oct 1997

Cutler N S, Heitman J, Cardenas M E

Abstract excerpt

Wortmannin is a natural product that inhibits signal transduction. One target of wortmannin in mammalian cells is the 110-kDa catalytic subunit of phosphatidylinositol 3-kinase (PI 3-kinase). We show that wortmannin is toxic to the yeast Saccharomyces cerevisiae and present genetic and biochemica...

Topics

1-Phosphatidylinositol 4-Kinase
Androstadienes
Cell Membrane
Enzyme Inhibitors
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Type C Phospholipases
Wortmannin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.