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Article

Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response.

PloS one - 12 Oct 2010

Hiratsuka Toru, Matsuzaki Shinsuke, Miyata Shingo, Kinoshita Mitsuhiro, Kakehi Kazuaki, Nishida Shinji, Katayama Taiichi, Tohyama Masaya

Abstract excerpt

BACKGROUND: Recently, several studies have reported Yokukansan (Tsumura TJ-54), a traditional Japanese medicine, as a potential new drug for the treatment of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress is known to play an important role in the pathogenesis of AD, particularly in n...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20967273
DOI: 10.1371/journal.pone.0013280
PMCID: PMC2953506

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EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20967273-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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