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Article

The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis.

Journal of neurochemistry - 1 Oct 2003

Kögel Donat, Schomburg Robert, Schürmann Tina, Reimertz Claus, König Hans-Georg, Poppe Monika, Eckert Anne, Müller Walter E, Prehn Jochen H M

Abstract excerpt

Endoplasmic reticulum (ER) stress is believed to play an important role in neurodegenerative disorders such as Alzheimer's disease. In the present study, we investigated the effect of the human amyloid precursor protein (APP) on the ER stress response in PC12 cells. Tunicamycin, an inhibitor of N...

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Source

Identifiers

PMID: 12969271
DOI: 10.1046/j.1471-4159.2003.02000.x

Genes

APP
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12969271-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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