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Article

Duplication of the chromosomal blaSHV-11 gene in a clinical hypermutable strain of Klebsiella pneumoniae.

Microbiology (Reading, England) - 1 Feb 2011

Duvernay Chloé, Coulange Laure, Dutilh Brigitte, Dubois Véronique, Quentin Claudine, Arpin Corinne

Abstract excerpt

In a collection of 110 clinical isolates of Klebsiella pneumoniae, a single strain, Kp593, was found to exhibit a mutator phenotype with a rifampicin mutation frequency 100-fold higher than the modal value for this species. Complementation experiments with the wild-type MutL, one of the main components of the methyl-directed mismatch repair system, allowed the mutator phenotype to be reversed. Sequencing revealed...

Topics

Aged, 80 and over
Cloning, Molecular
DNA, Bacterial
Drug Resistance, Bacterial
Female
Gene Duplication
Genetic Complementation Test
Humans
Klebsiella Infections
Klebsiella pneumoniae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

MutS DNA Mismatch-Binding Protein

Mutagenesis, Site-Directed

Mutation

Phenotype

Sequence Analysis, DNA

Virulence

beta-Lactamases

Source

Identifiers

PMID: 20966089
DOI: 10.1099/mic.0.043885-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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