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Structure and Function of the 3′ Terminal Six Nucleotides of the West Nile Virus Genome in Viral Replication

14 Jul 2004

Abstract excerpt

Using a self-replicating reporting replicon of West Nile (WN) virus, we performed a mutagenesis analysis to define the structure and function of the 3'-terminal 6 nucleotides (nt) (5'-GGAUCU(OH)-3') of the WN virus genome in viral replication. We show that mutations of nucleotide sequence or base pair structure of any of the 3'-terminal 6 nt do not significantly affect viral translation, but exert discrete...

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PMID: 15254187
DOI: 10.1128/jvi.78.15.8159-8171.2004

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