Article
ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relation with APOE genotype.
Journal of psychiatry & neuroscience : JPN - 1 Jan 2011
Vila-Rodriguez Fidel, Honer William G, Innis Sheila M, Wellington Cheryl L, Beasley Clare L
Abstract excerpt
BACKGROUND: Apolipoprotein E (apoE) and cholesterol play a critical role in synapse and myelin maintenance and integrity and are thus appealing candidates in the pathogenesis of schizophrenia and bipolar disorder. To explore the role of these 2 molecules, we quantified cholesterol and apoE levels in prefrontal grey and white matter in patients with schizophrenia, bipolar disorder and healthy controls....
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