Article
Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia.
Biological psychiatry - 15 Sept 2003
Dean Brian, Laws Simon M, Hone Eugene, Taddei Kevin, Scarr Elizabeth, Thomas Elizabeth A, Harper Clive, McClean Catriona, Masters Colin, Lautenschlager Nicola, Gandy Samuel E, Martins Ralph N
Abstract excerpt
BACKGROUND: It is unclear whether altered expression of a specific isoform of apolipoprotein E (apoE) is associated with the pathology of schizophrenia. METHODS: To address whether apoE may be involved in the pathology of schizophrenia, we measured the genotypic and allelic frequency of polymorphisms in its gene and transcriptional regulatory region in DNA from Brodmann's area (BA) 9 obtained postmortem from...
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